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Vicks Cough 7.33 mg 12 Lozenges with honey

  • Procter & Gamble S.r.l.
  • 031107028

Indicated in case of dry and irritating cough.

Immediate sedative action.

Deductible over-the-counter drug.

Enriched with honey.

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Therapeutic indications

Cough suppressant.

Dosage and method of use

Adults and adolescents over 12 years: 2 tablets every 6 - 8 hours up to a maximum of 8 tablets per day to dissolve in the mouth. Children up to 12 years: Dextromethorphan should not be used.


Hypersensitivity to the active substance, to structurally similar compounds, or to any of the excipients listed in paragraph 6.1. Do not use simultaneously and in the two weeks following therapy with MAO inhibitor antidepressant drugs (see par.4.5. Bronchial asthma, COPD (chronic obstructive pulmonary disease), pneumonia, breathing difficulties, respiratory depression, cardiovascular diseases, hypertension, hyperthyroidism, diabetes, glaucoma , prostatic hypertrophy, stenosis of the gastrointestinal and urogenital system, epilepsy, serious liver diseases. Do not administer to children under the age of 12. Pregnancy, particularly in the first trimester, breastfeeding (see section 4.6).

Side effects

Adverse reactions are listed below by system organ class and frequency, according to the following categories: Very common ≥ 1/10 Common ≥ 1/100, Immune system disorders: Not known: hypersensitivity reactions including anaphylactic reaction, angioedema , urticaria, pruritus, rash and erythema.Metabolism and nutrition disorders:Not known: diabetes mellitus.Psychiatric disorders:Very rare: hallucinations. Not known: psychosis.Nervous system disorders:Common: dizziness. Rare: drowsiness.Gastrointestinal disorders:Common: nausea, vomiting, gastrointestinal disorders and decreased appetite.Skin and subcutaneous tissue disorders:Rare: skin rashes.General disorders and administration site conditions:Common: fatigue. Not known: hyperpyrexia. Cases of dependence and abuse have been reported with dextromethorphan.Reporting of suspected adverse reactionsReporting suspected adverse reactions that occur after authorization of the medicinal product is important, as it allows continuous monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system at https://www.aifa.gov.it/content/segnalazioni-reazioni-avverse.

Special warnings

Treatment with dextromethorphan should not be continued beyond 5-7 days. If there is no therapeutic response within a few days, the doctor must reevaluate the situation. Dextromethorphan can be habit-forming. Following prolonged use, patients may develop tolerance to the medicinal product, as well as mental and physical dependence (see section 4.8). Cases of abuse and dependence on dextromethorphan have been reported. Caution is particularly recommended for adolescents and young adults, as well as in patients with a history of drug or psychoactive substance abuse.Risks arising from the concomitant use of sedative medicines such as benzodiazepines or related drugsConcomitant use of Vicks Cough and sedative medications such as benzodiazepines, or related medications, may cause sedation, respiratory depression, coma and death. Because of these risks, concomitant prescribing with sedative medicinal products should be reserved for patients for whom alternative treatment options are not available. If Vicks Cough is prescribed concomitantly with sedative medicinal products, the lowest effective dose should be used and the duration of treatment should be as short as possible. Patients should be carefully monitored for signs and symptoms of respiratory depression and sedation. In this regard, it is strongly recommended to inform patients and anyone caring for them in order to make them aware of these symptoms (see section 4.5).Serotonin syndromeSerotonergic effects, including the development of life-threatening serotonin syndrome, have been reported for dextromethorphan with concomitant administration of serotonergic agents, such as selective serotonin reuptake inhibitors (SSRIs), drugs that alter serotonin metabolism (including monoamine oxidase inhibitors[monoamine oxidase inhibitors, MAOI]) and CYP2D6 inhibitors. Serotonin syndrome may include mental status changes, autonomic instability, neuromuscular abnormalities, and/or gastrointestinal symptoms. If serotonin syndrome is suspected, treatment with Vicks Cough should be discontinued. Dextromethorphan is metabolised by hepatic cytochrome P450 2D6. The activity of this enzyme is genetically determined. Approximately 10% of the population slowly metabolizes CYP2D6. Exaggerated and/or prolonged effects of dextromethorphan may occur in poor metabolizers and patients with concomitant use of CYP2D6 inhibitors. Caution is therefore necessary in patients who are poor metabolisers of CYP2D6 or who use CYP2D6 inhibitors (see also section 4.5). A chronic cough may be an early symptom of asthma and therefore dextromethorphan is not indicated for the suppression of chronic or persistent cough (e.g. due to smoking, emphysema, asthma, etc.). Dextromethorphan must be administered with particular caution and only on medical advice if the cough is accompanied by other symptoms such as: fever, rash, headache, nausea and vomiting. In case of irritating cough with significant mucus production, treatment with dextromethorphan should be administered with particular caution and only on medical advice after a careful risk-benefit assessment. Administer with caution in subjects with impaired hepatic or renal function, especially in patients with severe impairment.Information on excipients with known effect: The product containssucrose(approximately 2 g per tablet) eglucose(1.2 g per tablet); to be taken into consideration in people suffering from diabetes mellitus or in case of low-calorie diets. Patients suffering from rare hereditary problems of fructose intolerance, glucose galactose malabsorption, or sucrase isomaltase insufficiency should not take this medicine. It is inadvisable to consume alcohol during therapy.

Pregnancy and breastfeeding

PregnancyThe results of epidemiological studies on a limited sample of the population did not indicate an increase in the frequency of malformations in children who were exposed to dextromethorphan during the prenatal period. However, these studies do not adequately document the timing and duration of treatment with dextromethorphan. Reproductive toxicity studies on animals do not indicate a potential risk for dextromethorphan for humans (see section 5.3). Dextromethorphan should not be used during the first three months of pregnancy; furthermore, since the administration of high doses of dextromethorphan, even for short periods, can cause respiratory depression in newborns, in the following months the drug must be administered only in case of actual need and after a careful evaluation of the benefits and risks.Feeding timeSince the excretion of the drug in breast milk is not known and a respiratory depressive effect on the newborn cannot be excluded, dextromethorphan is contraindicated during breastfeeding.

Expiration and conservation

This medicine does not require any special storage conditions.

Interactions with other drugs

MAO inhibitor drugsConcomitant administration of dextromethorphan with MAO inhibitor drugs is contraindicated. Furthermore, dextromethorphan should not be administered during or in the two weeks following the administration of monoamine oxidase inhibitor drugs. The association of these drugs can, in fact, induce the development of a serotonin syndrome characterized by the following symptoms: nausea, hypotension, neuromuscular hyperactivity (tremor, clonic spasm, myoclonus, increased reflex response and rigidity of pyramidal origin), hyperactivity of the autonomic nervous system (diaphoresis, fever, tachycardia, tachypnea, mydriasis) and altered mental state (agitation, excitation, confusion), up to cardiac arrest and death.Linezolid and sibutramineCases of serotonin syndrome have also been reported following concomitant administration of dextromethorphan with linezolid or sibutramine.Central nervous system inhibitor drugsConcomitant administration of dextromethorphan with drugs with an inhibitory effect on the central nervous system such as hypnotics, sedatives or anxiolytics, or with alcohol, may lead to additive effects on the central nervous system. Concomitant use of opioids and sedative medicines such as benzodiazepines, or related drugs, increases the risk of sedation, respiratory depression, coma and death due to additive CNS depressant effect. The dosage and duration of concomitant treatment should be limited (see section 4.4).CYP2D6 inhibitorsDextromethorphan is metabolised by CYP2D6 and has extensive first pass metabolism. Concomitant use of strong inhibitors of the CYP2D6 enzyme can increase dextromethorphan concentrations in the body to levels many times higher than the normal value. This increases the patient's risk for toxic effects of dextromethorphan (agitation, confusion, tremor, insomnia, diarrhea, and respiratory depression) and for the development of serotonin syndrome. Potent inhibitors of CYP2D6 are fluoxetine, paroxetine, quinidine and terbinafine. When used concurrently with quinidine, plasma concentrations of dextromethorphan are increased up to 20-fold, resulting in increased adverse CNS effects of the agent. Amiodarone, flecainide and propafenone, sertraline, bupropion, methadone, cinacalcet, haloperidol, perphenazine and thioridazine also have similar effects on the metabolism of dextromethorphan. If concomitant use of CYP2D6 inhibitors and dextromethorphan is necessary, the patient should be monitored and the dose of dextromethorphan may need to be reduced.Secretolytic drugsIf dextromethorphan is used in combination with secretolytic drugs, the reduction of the cough reflex can lead to severe mucus accumulation.Grapefruit juiceGrapefruit juice may increase the absorption, bioavailability and elimination of dextromethorphan, resulting in an increase in its toxicity and a decrease in its effect.


Symptoms and SignsDextromethorphan overdose may be associated with nausea, vomiting, dystonia, agitation, confusion, drowsiness, stupor, nystagmus, increased muscle tone, cardiotoxicity (tachycardia, abnormal ECG including QTc prolongation), ataxia, toxic psychosis with hallucinations visual, hyperexcitability. In case of massive overdose, the following symptoms may be observed: coma, respiratory depression, convulsions and urinary retentionManagementActivated charcoal may be administered to asymptomatic patients who have ingested overdoses of dextromethorphan within the previous hour. For patients who have ingested dextromethorphan and are sedated or comatose, naloxone, in doses usual for the treatment of opioid overdose, may be considered. Benzodiazepines can be used for convulsions and benzodiazepines and external cooling measures for hyperthermia due to serotonin syndrome. If necessary, resort to intensive medical care (in particular intubation, ventilation). Precautions may be necessary to safeguard heat loss and replenish fluids. Treatment of overdose may require gastric lavage and treatment of specific symptoms. Do not administer centrally acting emetics.

Active principles

Each tablet contains:active principle: dextromethorphan base 7.33 mg. Excipients with known effects: sucrose and glucose. For the full list of excipients, see section 6.1.


Sucrose, liquid glucose, honey, levomenthol, honey flavouring, caramel flavouring.


Data sheet

12 tablets
Product Type
ATC code
ATC description
Therapeutic Group
Opioid antitussives
Active principle
dextromethorphan (DC.IT)
Pharmaceutical form
candy pastille
Type of Administration
cpr / cps / pills / confetti in blister packs
12 candies / tablets
Quantity of the Active Ingredient
Recipe required
OTC - self-medication medicine
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