Description
Concentrated food supplement based on bromelain extracted from pineapple with high enzymatic activity and enriched with SOD to counteract the damage of oxidative stress. Promotes the drainage of body fluids, supports the functionality of the microcirculation and reduces the imperfections of cellulite, improving the tone and firmness of the skin. Furthermore, it has an important anti-inflammatory action and, taken after meals, promotes digestion even in the case of large meals.

Property
-Pineapple: made up for 90% from water, but there are also: sugars, essential oil, organic acids (especially oxalic, citric and malic), vitamins A, B and C, amino acids, fibers and minerals (in particular iron, calcium, manganese and potassium). Bromelain is concentrated in the fruit, but to a greater extent in the stem that supports it, an enzymatic mix of protease, phosphatase, peroxidase, amylase and cellulase at the base of all the biological activities recognized in the extract. Bromelain is active in a very wide pH range, between 4.5 and 9.5, is rapidly absorbed in the intestine and has a half-life of approximately 6-9 hours. In it, the proteolytic activity is predominant and justifies the use of the extract to support digestion, after a meal. Thanks to characteristics similar to those of pepsin, it is in fact able to accelerate the digestion of proteins, preventing the formation of intestinal gas and the feeling of abdominal heaviness.
A further advantage conferred on the well-being of the legs derives from the platelet antiplatelet activity of bromelain, whose administration also involves a lower activation of the platelet activation itself. As a fibrinolytic, it inhibits thrombus formation and can be used successfully in acute thrombophlebitis. It can also contribute to the resorption of hematomas. Due to the high concentration of antioxidant molecules, pineapple extract can also contribute to cardiovascular well-being, hindering the formation of atherosclerotic plaques in subjects with high hypercholesterolemia. Finally, the pineapple stem has an anti-inflammatory action with an unknown mechanism, probably dependent on a proteolytic modulation of the molecular cascade underlying the inflammatory process. In addition to contributing to the treatment of inflammatory states associated with trauma and edema, thanks to its effect on the immune response it is also showing promise in the management of chronic disorders such as asthma, sinusitis and rheumatoid arthritis, where it reduces inflammation and eosinophil infiltration. and leukocytes. It is also used in pain control: it reduces acute knee pain in a dose-dependent manner in case of osteoarthritis, post-operative pain and edema.
-Superoxide dismutase: it is a very important antioxidant present in almost all cells exposed to oxygen. It is the key enzyme that inactivates superoxide, the most reactive radical species that can damage membrane lipids, proteins and DNA. SOD has been used for years in the general medical field for the management of anti-inflammatory diseases such as osteoarthritis, sports injuries and joint arthrosis of the knee. It is also used for the protection of cardiovascular risk, for the protection of DNA from damage caused by oxidative stress and to counteract the excess of free radicals due to sports activity. It also improves cognitive faculties, is useful in stress control and can have immunoprotective actions.
-SuperOx-D: is a patented extract obtained from Carrot which acts by inactivating the peroxide radical and also other radical forms that are generated upstream and downstream through quenching mechanisms.
-Centella: it is a plant of Ayurvedic translation that counteracts the imperfections of cellulite and supports the well-being of the microcirculation. In particular, it stimulates the activity of fibroblasts and the synthesis of proline and alanine, amino acids essential for the formation of collagen. Normalizes the perivascular connective tissue with improvement of the tone and elasticity of the venous wall. In addition, it stimulates the cells and tissues that participate in the healing process.

Ingredients
Demineralized water, maltodextrin, inulin, bromelain from pineapple (Ananas comosus (L.) Merr.) Stem 2,500 GDU / g, flavors; acidifiers: citric acid, malic acid; Superox-D superoxide dismutase 11,000 U / g from carrot (Daucus carota L.) root eg; preservatives: potassium sorbate, sodium benzoate; thickener: xanthan gum; centella [Centella asiatica (L.) Urb.] leaves eg tit. 2% triterpenes, pineapple [Ananas comosus (L.) Merr.] stem eg tit. 0.1% bromelain; sweetener: steviol glycosides.

Without gluten.

Nutritional characteristics

Average values for 10 ml
Power	49.95 kJ 11.86 kcal
Fat of which saturated of which monounsaturated of which polyunsaturated
Carbohydrates of which sugars	2.43 g 0.26g
Fibers
Proteins
salt	9.15 mg
Bromelain	500 mg
Superoxide dismutase	20 mg
Centella eg	10 mg
Pineapple eg	10 mg

How to use
We recommend taking 10 ml per day to be diluted in 250 ml of water and to be consumed preferably in the morning to support drainage or in small sips during meals to promote digestion.

Warnings
Do not use in pregnancy, lactation, pre-operative period, peptic ulcer, hepatitis; it could increase the absorption and half-life of antiplatelet agents, tetracyclines, hypoglycemic agents.

storage
Store at room temperature.
Validity for intact packaging: 36 months.

Format
Bottle of 200 ml.

Cod. 180925

Bibliography
Barun KB "Bromelain: an overview". Nat. Prod. Rad. 7 (4): 359-363. 2008.
Maurer HR "Bromelain: biochemistry, pharmacology and medical use". Cell Mol. Life Sci. 58 (9): 1234-45. 2001.
Nguyen NH. et. to the. "Anti-oxidative effects of superoxide dismutase 3 on inflammatory diseases". J. Mol. Med. (Berl). doi: 10.1007 / s00109-019-01845-2. 2019.
Ordesi P. et al. "Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study". Quintessence Int. 45 (8): 679-84. 2014.
Rathnavelu V et al. "Potential role of bromelain in clinical and therapeutic applications". Biomed Rep. 5 (3): 283-288. 2016.
Vouldoukis I. et al. "Antioxidant and anti-inflammatory properties of a Cucumis melo LC. Extract rich in superoxide dismutase activity". J. Ethnopharmacol. 94 (1): 67-75. 2004.