Description
Sterile solution.
Tris-EDTA + N-Acetyl Cysteine (NAC) buffer with high hygienic strength for dogs and cats.
Tris-EDTA (Ethylene Diamine Tetracetic Acid) has bactericidal activity on non-growing bacteria located within the biofilm ( Ciofu et al, 2017 ); in association with Tromethamine (Tris) it damages the walls of bacterial cells and increases penetration inside bacterial membranes; it is well tolerated and not ototoxic; acts synergistically with chlorhexidine ( Guardabassi et al, 2010 ). Recently, in vitro work has demonstrated that Tris-EDTA is a more than effective support in the treatment of chronic cases of Pseudomonas otitis with the presence of potential biofilm combined with antibiotics ( Pye et al, 2014 ).
NAC is an N-acetylated derivative of the amino acid cysteine, it has mucolytic action, therefore destroys the production of exopolysaccharides, thus weakening the EPS matrix. It has recently been used in eight clinical trials as an adjuvant treatment to destroy mature biofilm and prevent its formation and has demonstrated an excellent safety and efficacy profile.
The association of Tris-EDTA and NAC on the skin and in the ear before the application of topical products such as chlorhexidine, antibiotics, synthetic antimicrobial peptides, therefore allows an increase in the permeability of the mature biofilm and, consequently, its disintegration , effectively supporting the overcoming of the problem of resistance to the classic antibacterial therapeutic approach.

Instructions for use
1. Apply pressure on the top of the bottle until the capsule breaks completely.
2. Shake the bottle.
3. Using the syringe found inside the package, collect the quantity to be used according to the veterinary surgeon's instructions.
In the ear canal: spray adequately and massage at the base of the ear.
On the skin: spray until the affected area is completely soaked.
Repeat the treatment as needed or as indicated by the veterinary surgeon.

Format
120 ml bottle.

Code PP3310001